Michael John Paldino1, Rudolph Pienaar2,
1Radiology, Children's Hospital Boston, Boston, MA, United States; 2Newborn Medicine, Children's Hospital Boston, Boston, MA, United States; 3Neurology, Children's Hospital Boston, Boston, MA, United States
Polymicrogyria consists of abnormal cortical lamination, with most severe involvement of layer 5. This pathologic description predicts abnormal white matter connectivity primarily within projection pathways. We have demonstrated a clinically-relevant impact of polymicrogyria on the arcuate fasciculus in pediatric patients with polymicrogyria. These preliminary results suggest a significant effect on the establishment of cortico-cortical connections and furthermore imply abnormal cortical structure beyond layer 5 in patients with polymicrogyria. These data promulgate the potential for tract-based measures of connectivity to probe cortical structure.