Yee Kai Tee1, Michael A. Chappell1,2, Jingyi Xie2, Stephen J. Payne1
1Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, Oxfordshire, United Kingdom; 2Oxford Centre for Functional MRI of the Brain, University of Oxford
Quantitative CEST experiments often entail sampling across a range of saturation frequency offsets, the sampling schedule commonly being evenly distributed. Recently, an uneven sampling schedule, which empirically placed samples at key parts of the spectrum and was determined through repeated MR data acquisition, has been shown to be superior. In this work, an optimal sampling schedule which is based on the sensitivity functions of the parameters of interest was sought to improve the precision of parameter estimation. Simulated results indicate that the resulting OSS offers improved accuracy for the estimation of amide proton exchange rate and water centre frequency offset.