SyN Based Multimodal Investigation on a Small Cohort of Patients Affected with Amnesic Mild Cognitive Impairment

Fabrizio Fasano¹, Chiara Ganazzoli¹, Simona Gardini¹, Fabio Sambataro², Letizia Concari¹, Paolo Caffarra¹

The recently developed SyN registration method is applied to a multimodal investigation (morphometric + transverse relaxometry based iron content evaluation) on a small cohort of patients affected with Amnesic Mild Cognitive Impairment. The aim of the study is to investigate the early stage of the disease through the help of the attested powerful registration method combined with the multimodality approach potentiality. Our morphometric findings, although not significant at the cluster level, show reasonable differences between the a-MCI group and the control group. On the other hand the relaxometry investigation was not able to find any difference between groups.