Irtiza Ali Gilani1, Raimo Sepponen2
1Advanced Magnetic Resonance Imaging Centre, Low Temperature Laboratory, Aalto University, Espoo, Uusima, Finland; 2Department of Electronics, Aalto University, Espoo, Uusima, Finland
Rotating frame relaxation rates, T1ρ and T2ρ, are noninvasive and sensitive markers of the neurodegeneration processes in diseases, such as, Alzheimer's and Parkinson's. A comprehensive review of contemporary MRI methods, that can be employed to probe the biophysical mechanisms affecting the T1ρ and T2ρ relaxations of the human tissue, is presented. Spin-Locking and adiabatic radiofrequency irradiation schemes are compared. Additionally, different MRI acquisition strategies for accurate and precise quantitative imaging at the high and ultra-high magnetic field are reviewed.