Abstract #0190

Precise Ex-Vivo Histological Validation of Heightened Cellularity in Regions of Dark ADC in Three Cases of High-Grade Glioma

Peter S. LaViolette¹, Elizabeth J. Cochran², Alex D. Cohen³, Mona Al-Gizawiy¹, Scott D. Rand, Jennifer Connelly⁴, Mark G. Malkin⁵, Wade M. Mueller⁶, Kathleen M. Schmainda⁷

¹Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; ²Pathology, Medical College of Wisconsin, Milwaukee, WI, United States; ³Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; ⁴Neurology, Medical College of Wisconsin; ⁵Neurology & Neurosurgery, Medical College of Wisconsin; ⁶Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States; ⁷Radiology and Biophysics, Medical College of Wisconsin

AFMM (ADC FLAIR MisMatch) is defined as an area of low ADC within FLAIR abnormality associated with a brain tumor. The aim of this study is to determine if areas of AFMM represent increased cellularity by histologic analysis of spatially-correlated ex-vivo issue acquired and processed in three patients with high grade gliomas.