Abstract #0204

Cerebrovascular Reactivity in the Brain White Matter: Magnitude, Temporal Delays & Age Effects

Binu P. Thomas¹,², Peiying Liu¹, Denise Park³, Matthias J.P. van Osch⁴, Hanzhang Lu¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; ²Bioengineering, University of Texas Southwestern Medical Center/University of Texas at Arlington, Arlington, TX, United States; ³Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, United States; ⁴Radiology, Leiden University Medical Center, Leiden, Netherlands

Vascular properties of brains white matter (WM) were examined. Cerbrovascular reactivity (CVR), baseline cerebral blood flow (CBF) and structural MPRAGE scans were obtained from healthy volunteers: 15 young (275) and 15 elderly (757) years. Temporal delay in BOLD CVR response from gray matter (GM) to WM was calculated. Response was slower in young (20.8 sec) and faster in older subjects (12.26 sec), (p=0.003). The response amplitude (%BOLD/mmHgCO2) is higher in WM (p=0.048) and lower in GM (p=0.005) in older subjects compared to young. Baseline CBF was higher in WM (p=0.072) and lower in GM (p=0.001) in old compared to young.