Sangjune Laurence Lee1, Warren Foltz1, Brandon Driscoll1, Ali Fatemi1, Cynthia Menard1, Catherine Coolens1, Caroline Chung1
1Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
Determining the arterial input function (AIF) is critical for the accuracy of kinetic modeling of DCE MRI measures. However, the magnitude signal derived AIF suffers from in-flow, slice profile, and T2* effects. Phase signal has been shown to be an alternative method of acquiring the AIF data. Here, we evaluate the accuracy of AIFs derived from the magnitude and phase signal in a dynamic flow phantom, providing a controlled, gold-standard framework. The phase-derived AIF approached actual peak Gd-DTPA concentrations within all imaging slices and at tested flow rates up to 7.5 mL/s, while the magnitude-derived AIF was grossly attenuated.