Zechen Zhou1, Rui Li1, Chun Yuan1, 2
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China; 2Department of Radiology, University of Washington, Seattle, WA, United States
Currently, Quadruple Inversion Recovery (QIR) prepared TSE sequence is a common black blood method to image the pre- and post- contrast enhanced vessel wall which can detect the neovasculature and inflammation in atherosclerotic plaque. However, this QIR prepared TSE technique is limited by the acquisition efficiency and partial volume effect. In this work, we first explained the principle of Phase Sensitive Double Inversion Recovery (PSDIR) and then investigated a time efficient 3D isotropic high resolution PSDIR based T1 insensitive flow suppression vessel wall imaging technique. This technique can further improve the CNR between lumen and vessel wall and be potentially applied for dynamic contrast enhanced black and white blood vessel wall imaging.