Alejandro Roldn-Alzate1, Catherine Hines, 12, Rashmi M. Agni3, Diego Hernando1, Karl K. Vigen1, 4, Gavin Hamilton5, Mark Bydder5, Claude Sirlin5, Scott B. Reeder1, 4
1Radiology, University of Wisconsin, Madison, WI, United States; 2MERK; 3Department of Pathology, University of Wisconsin - Madison, Madison, WI, United States; 4Medical Physics, University of Wisconsin, Madison, WI, United States; 5University of California San Diego
Synopsis (100 words maximum): NAFLD is the most common type of chronic liver disease affecting an estimated 90-100 million people in the US alone, including 10% of children. Liver biopsy is the current gold standard for diagnosis of NAFLD, but is limited due to sampling variability, cost and risk. The purpose of this study is to validate two quantitative MRI methods (complex, magnitude) for accurate diagnosis and grading of NAFLD using MRI. Single voxel MR spectroscopy and non-targeted liver biopsy are used as reference standards in this study. Excellent correlation between both MRI methods and MRS, and very good correlation with biopsy was found.