James Alastair Meakin1, 2, Mark William Little3, 4, Thomas William Okell1, Suzie Anthony3, Raman Uberoi3, Peter Jezzard1
1FMRIB Centre, University of Oxford, Oxford, United Kingdom; 2Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom; 3Department of Radiology, John Radcliffe Hospital, Oxford, United Kingdom; 4Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom
There is a need for accurate assessment of perfusion to lower limb skeletal muscle in patients with peripheral arterial disease to aid diagnosis and management. We have developed a Velocity Selective ASL (VSASL) sequence to provide quantitative measures of resting perfusion in calf skeletal muscle, without the transit delay errors associated with Continuous ASL. In this study, we optimised the acquisition and demonstrated the feasibility of VSASL for quantifying skeletal muscle perfusion at rest in five healthy volunteers.