Ek T. Tan1, Vincent B. Ho2, 3, James F. Glockner4, Daniel V. Litwiller5, Christopher J. Hardy1, Thomas K. Foo1
1GE Global Research, Niskayuna, NY, United States; 2Uniformed Services University of the Health Sciences, Bethesda, MD, United States; 3Walter Reed National Military Medical Center, Bethesda, MD, United States; 4Mayo Clinic, Rochester, MN, United States; 5GE Healthcare, Rochester, MN, United States
A novel dynamic virtual bolus (DVB) method that does not require the administration of gadolinium-chelate contrast media was demonstrated. Using cine phase-contrast acquisition, the velocity field was integrated and deciphered into a bolus signal for each time frame or cardiac phase. The typical result from DVB of the peripheral vessels was a movie with large FOV, long time-course (10 or more seconds) with high temporal resolution of 55 msec. The bolus progression as well as arterial pulsatility is well-visualized during systole and diastole. In time-trial simulations, sub-second accuracies were recorded. The algorithm was region-based to negotiate complex vascular trees and small vessels.