Fiona M. Fennessy1, 2, Andriy Fedorov1, Sandeep N. Gupta3, William M. Wells1, Robert V. Mulkern1, 4, Clare M. Tempany1
1Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2Radiology, Dana Farber Cancer Institute, Boston, MA, United States; 3GE Global Research Center, Niskayuna, NY, United States; 4Radiology, Children's Hospital Boston, Boston, MA, United States
We sought to determine if Ktrans and ve differed within ADC-matched prostate tumor voxels, confirmed by pathology at radical prostatectomy. A deformable registration technique was used to recover image distortions on DWI, registered to the DCE series. We found a significant difference between tumor and normal tissue for ADC, Ktrans , and ve. Using Logistic regression analysis, Ktrans has a contributory role to ADC for tumor detection. However, weak correlations between both Ktrans and ve and the ADC values, underscoring the different pathophysiological processes assessed with DWI and DCE, and need for a multiple-parameter strategy approach for prostate tumor assessment.