Jennifer W. Chong1, Natalie Yang2, Sarah J. Jenkins3, Errol Colak1, Shalini Anthwal1, Andrew A. Common1, Vikram Prabhudesai1, Anish Kirpalani1
1Department of Medical Imaging, University of Toronto, St. Michael's Hospital, Toronto, ON, Canada; 2Department of Radiology, Austin Health, Heidelberg, Australia; 3Department of Diagnostic Imaging, Memorial University, St. John's, NL, Canada
A decrease in uterine fibroid enhancement on pelvic MRI is routinely used to monitor patients' response to uterine fibroid embolization (UFE). In this prospective cohort study of 50 patients (88 uterine fibroids), we examined whether the ADC from diffusion-weighted MRI also changed post-UFE. We found a statistically significant rise in the mean ADC of fibroids post-UFE. We also found that fibroids which have more residual contrast enhancement post-UFE had a higher pre-UFE ADC. ADC may therefore have a clinically important role in predicting treatment response.