Wei Wang1, 2, Nguyet M. Nguyen3, Jinbang Guo1, Yulin Chang2, Dmitriy A. Yablonskiy2, Richard A. Pierce3, Jason C. Woods, 12
1Physics, Washington University in St. Louis, St. Louis, MO, United States; 2Radiology, Washington University in St. Louis, St. Louis, MO, United States; 3Internal Medicine, Washington University in St. Louis
Pneumonectomy (PNX) is a robust, established model of compensatory lung growth. Understanding the time course and the mechanism of compensatory lung growth will promote understanding of post-natal lung growth and regeneration. 3He lung morphometry has been successfully implemented in humans for years, and was recently developed and validated in mice. Here we image in-vivo morphometry at baseline and serially assess compensatory growth after PNX in mice via 1H and 3He MRI. The results demonstrate that in addition to growth of alveolar size, the total lung volume, alveolar number and lung compliance are restored to baseline levels by compensatory lung growth.