Halleh Ghaderi1, 2, Abbas Sadikot3, Jennifer Campbell2, G. Bruce Pike2, 3
1Biomedical Engineering, McGill University, Montreal, Quebec, Canada; 2McConnell Brain Imaging Center, Montreal, Quebec, Canada; 3Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
Deep brain stimulation (DBS) is a surgical treatment for Parkinsons disease that involves implanting electrode in thalamus of awake patients. The success of this surgery is highly influenced by the accuracy of target localization. Current DBS planning is limited to visual inspection of anatomical MRI and micro-electrode recording during the surgery to find the target. This may require multiple insertions, thus increasing the risk of complications. Therefore, the conventional target localization is complex, tedious and time-consuming for surgeon and uncomfortable for an awake patient. This study proposes a non-invasive, automatic, rapid technique to accurately localize thalamic nuclei using a combination of Diffusion imaging and functional MRI.