Ramona Lorenz1, Jelena Bock1, Alexander Jonathan Barker1, Florian von Knobelsdorff-Brenkenhoff2, Jan Gerrit Korvink3, 4, Michael Markl5
1Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany; 2Dept. of Cardiology and Nephrology, Charit Medical University Berlin, Working group on cardiovascular MRI, and HELIOS Klinikum Berlin-B, Berlin, Germany; 3Dept. of Microsystems Engineering - IMTEK, University of Freiburg, Freiburg, Germany; 4Freiburg Institute of Advanced Studies (FRIAS), University Freiburg, Freiburg, Germany; 5Dept. of Radiology and Biomedical Engineering, Northwestern University, Chicago, United States
This study provides a quantitative analysis of blood flow helicity within the aorta using 4D flow sensitive MRI. Helical flow was evaluated in a study with 12 healthy volunteers and 20 patients with aortic valve disease. Time resolved mean helicity along the entire aorta was quantified for each subject with good test-retest reliability. All healthy subjects show a consistent direction of rotation over the entire aorta with increased helicity in the aortic arch and good inter-individual agreement, while patients reveal strong variations in the distribution and a significant increase of helical flow in the aorta.