Jeff Snyder1, Martin Haas1, Iulius Dragonu1, Juergen Hennig1, Maxim Zaitsev1
1Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany
Excitation of arbitrarily-shaped three dimensional voxels in spectroscopy is investigated in vivo in the healthy brain to alleviate voxel geometry restrictions and consequently improve localization of specific regions and decrease partial-volume effects. The technique uses a 3D spatial/spectral excitation scheme in a pulse-acquire type sequence to achieve a broad bandwidth and allow acquisition of the signal in less than 1 ms following the pulse onset. 3D spatial localization is demonstrated with a gradient-echo sequence implementing the specialized pulses, and LCModel analysis is used for spectral evaluation of brain metabolites.