Francesco Giorlando1, Paul Fletcher2, Peter Brotchie3, 4
1Psychiatry, University of Melbourne, Geelong, VIC, Australia; 2Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 3Radiology, Barwon Medical Imaging, The Geelong Hospital, Geelong, VIC, Australia; 4The University of Melbourne, Melbourne, VIC, Australia
An fMRI trial of temporal dissociation induced by ketamine was conducted in 27 volunteers. The study used an event related paradigm and was placebo controlled. The Temporal Order Assessment task was the main measure of interest. Significant dorsal anterior cingulate cortex and inferior frontal cortex activation was found with inverted temporal judgements. Ketamine administration was associated with increased left temporo-parietal-occipital junction activity. The results are discussed with relation to the cortico-limbic theory of dissociation and the implications for theories of temporal perception.