Artem Shatillo1, Joanna Huttunen1, Antti Airaksinen1, Juha-Pekka Niskanen1, 2, Olli Grohn1
1Department of Neurobiology, University of Eastern Finland, Kuopio, Finland; 2Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
Spreading depolarization (SD) waves are typically observed only under pathophysiological conditions. We detected spontaneously occurring SDs in 9 Sprague-Dawley rats during 1 hour long BOLD fMRI study under medetomidine sedation. Total of 17 waves were detected lasting for 193.3 58.8 sec in one cortical ROI, propagating with speed of 2.930.6 mm/min. Observed propagation pattern and involvement of subcortical regions is atypical for classical spreading depolarization described in literature and needs further investigations.