Gerard Thompson1, Sha Zhao1, Goeff JM Parker1, Alan Jackson1
1University of Manchester, Manchester, United Kingdom
Quantitative magnetization transfer (qMT) has been used to study white matter diseases. qMT bound fraction (f) is considered to be a proxy of WM myelination. Since glial tumors arise in and invade white matter, changes in f may represent both affected white matter, and diagnostic information about the solid tumor component. Here we demonstrate that while f is not specific at distinguishing glioma grade or subtype, it is sensitive for the detection of solid tumor, and tumor and age-related white matter change in vivo. We also demonstrate that f can be derived accurately without the need for B1 correction at 3T.