N. Agarwal1, L. D'Silva1, E. M. Kan2, S. K. Verma1, S. Seramani1, K. C. Ng2, E. A. Ling3, J. Lu2, S. Sendhil Velan1
1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore; 2Combat Care Laboratory, Defence Medical and Environmental Research Institute, DSO National Lab, Singapore, Singapore; 3Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Traumatic Brain Injury (TBI) can cause lasting neuropsychological damage and impair the day-to-day functionality for survivors. In this study, we have investigated the changes in brain morphology, cognitive function and metabolism affected by fluid percussion injury in rodent models with Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (MRS). The current study demonstrates good correlation in results obtained by DTI and 1H MRS to track white matter changes in the traumatic brain injury model in rodents. This suggests that regional cerebral changes in ADC and NAA/Cr values may serve as a possible diagnostic marker for cognitive performance after TBI.