Miriam Scadeng1, Seanna Grob2, Karen Duong-Polk2, Robert Weinreb2, James Lindsey2
1Radiology, University Of California San Diego, La Jolla, CA, United States; 2Opthalmology, University Of California San Diego, La Jolla, CA, United States
Injection of MnCl into the eye can increase contrast in visual system neuronal pathways when imaged by MRI. As an in-vivo technique, MEMRI has the potential to be used for repeated studies. However, Mn2+ is known to be neurotoxic, and limited published data exists on how toxic MnCl is to different ocular structures when injected into the eye. This is of particular importance for experiments that use this approach to longitudinally follow degenerative changes in models of neuronal disease. This study determines the effect of a range of MR visible MnCl doses upon the integrity of various ocular structures.