Geoffrey Topping1, Andrew Yung2, Paul Schaffer3, Piotr Kozlowski2, Thomas Ruth3, Vesna Sossi1
1Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada; 2MRI Research Centre, University of British Columbia, Vancouver, British Columbia, Canada; 3Nuclear Medicine, TRIUMF, Vancouver, British Columbia, Canada
Manganese concentration was measured in the rat brain using MRI T1 mapping and positron emission tomography with the radiotracer Mn-52 after IP and IV injections. Within the brain, results are similar between modalities, with short-term Mn accumulation seen prominently in the pituitary. This similarity suggests pharmacological effects do not significantly affect short term Mn uptake.