Varan Govind1, Khema Sharma2, Andrew A. Maudsley1, Kristopher L. Arheart3, Gaurav Saigal1, Sulaiman Sheriff1
1Radiology, University of Miami, Miami, FL, United States; 2Neurology, University of Miami; 3Epidemiology and Public Health, University of Miami
In previous studies, proton MR-observed brain metabolite data analysis in the primary motor cortex and corticospinal tract was performed using manually drawn regions-of-interest (ROIs). Such an approach is bound to have subjectivity introduced by the manual selection of ROIs. In this study, a comprehensive analysis of brain metabolite [N-acetyl aspartate (NAA), total-creatine (Cre) and total-choline (Cho)] alterations in the CST of subjects with ALS was performed using a 3D CST atlas.