Ai-Ling Lin1, Ethan Poteet2, Fang Du1, Andrew Bresnen1, Shiliang Huang1, Yi Wen2, Shao-Hua Yang2, Timothy Q. Duong1
1Research Imaging Institute, University of Texas Health Science Center at San Anotnio, San Antonio, TX, United States; 2, Institute for Alzheimers Disease and Aging Research, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, United States
Methylene blue (MB) helps to sustain ATP production by acting as an electron donor in the mitochondrial electron transport chain. MB has long been used to treat methemoglobinemia and it has recently been shown to have neuroprotective in a number of neurological diseases. This study evaluated the metabolic and hemodynamic effects of MB in vivo. Cerebral metabolic rate of oxygen cerebral metabolic rate of glucose, oxygen extraction fraction and cerebral blood flow were measured in those conditions in rats. Comparisons were made with In Vitro studies that measured glucose and oxygen consumption.