Octavia Biris1, 2, Saurabh Shah3, Christopher Glielmi3, Daniel C. Lee4, James C. Carr1, Timothy J. Carroll1, 2
1Radiology, Northwestern University, Chicago, IL, United States; 2Biomedical Engineering, Northwestern University, Evanston, IL, United States; 3Customer Solutions Group, Siemens Medical Solutions USA, Inc., Chicago, IL, United States; 4Feinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, United States
Absolute quantification of myocardial blood volume (ml/100g) may provide important information about myocardial viability in coronary artery disease and in heart transplants, where the formation of fibrotic tissue and global MBV reduction in the myocardium precedes organ rejection. We show a first observation of quantitative myocardial blood volume and water proton exchange in human volunteers with an intravascular contrast agent. Myocardial blood volume was calculated pixel-by-pixel from steady-state T1-weighted signal before and after administration of contrast agent. We show intra- to extra-vascular water exchange in the myocardium to fit a previously published two compartment slow water exchange model.