Roshan Livingstone1, Paul Begovatz1, Sabine Link1, Bettina Nowotny1, Birgit Klueppelholz2, Guido Giani2, Juergen Bunke3, Michael Roden1, 4, Jong-Hee Hwang1
1Institute of Clinical Diabetology, German Diabetes Center, Dsseldorf, Germany; 2Institute for Biometry and Epidemiology, German Diabetes Center, Dsseldorf, Germany; 3Philips Healthcare, Hamburg, Germany; 4Department of Metabolic Diseases, University Clinics, Heinrich Heine University, Dsseldorf, Germany
1H-MRS is considered the gold standard for liver fat measurements, however, it is unclear whether H-1 MRS is more accurate for the pancreas than DIXON methods. A flexible 2-point mDIXON method (TE1/TE2 = 1.12/2.0 ms) was compared to 1H-MRS for fat fraction of the liver and pancreas in 19 volunteers. Values of hepatic fat fraction by mDIXON and 1H-MRS correlated well with each other (r = 0.96, p<0.00001), however, in the pancreas a correlation of (r=0.66, p<0.001) was found, which was probably attributed to differences in the amount and distribution of fat between the two organs.