Eleanor F. Cox1, Abeed H. Chowdhury2, Dileep N. Lobo2, Susan T. Francis1
1SPMMRC, School of Physics & Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Nottingham Digestive Diseases Centre BRU, University of Nottingham, Nottingham, Nottinghamshire , United Kingdom
Infusions of large volumes of saline (an unbalanced crystalloid) can cause hyperchloremic acidosis, which has previously been shown to reduce renal blood flow in canine models. We predicted that a balanced crystalloid with an electrolyte composition closer to human blood plasma would not produce this effect on renal blood flow and perfusion. Following 2 litre infusions over 60 minutes in 12 healthy males, the renal artery blood flow velocity and renal cortical perfusion were significantly reduced following the unbalanced crystalloid, whilst no significant change in flow or perfusion were found for the balanced crystalloid.