1Radiology, University of Virginia, Charlottesville, VA, United States, 2Boimedical Engineering, University of Virginia, Charlottesville, VA, United States, 3Pediatric Pulmonology, University of Virginia, Charlottesville, VA, United States, 4Xemed, Durham, NH, United States, 5Vertex Pharmaceuticals Incorporated, Cambridge, MA, United States
Summary: Ventilation MRI of the lung has been performed with hyperpolarized helium-3 and xenon-129. It is not known whether the distribution within the lung of inhaled xenon-129, which has an atomic weight 43 times that of helium-3, is different from that for helium-3. In this study of 6 subjects with cystic fibrosis (CF), the size, location, and relative severity of the defects were nearly identical with helium-3 and xenon-129 for most subjects. In a few subjects the defects were more conspicuous, larger, and/or more numerous with xenon-129, which suggests xenon-129 may be more sensitive to areas of partial airflow obstruction.