Jie Huang1, Sarah Schafer1, Lori Hoisington1, Gerald Aben1
1Department of Radiology, Michigan State University, East Lansing, MI, United States
This study validated lesion washout volume fraction as an MRI biomarker for improving the characterization of suspicious contrast-enhancing breast lesions. Using a sample consisting of 94 contrast-enhanced lesions with histopathology reports, the study found that the washout volume fraction was significantly larger for the malignant tumors than the benign lesions, reflecting the hypervascularity associated with tumor angiogenesis. It provides an additional MRI biomarker for improving the characterization of suspicious contrast-enhancing breast lesions, and the biomarker has the potential to improve the computer-based assessment in breast MRI.