Andreia Silva1, 2, Angelika Hoffmann1, Alexander Klibanov1, Max Wintermark1, Sara Reis1, John Mugler III1, Jaime Mata1
1Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, United States; 2IBEB -FCUL, Universidade de Lisboa, Lisboa, Portugal
The use of contrast agents and therapeutic agents in the brain is limited by the blood-brain barrier (BBB), which restricts their entry into the brain. Focal or regional opening of the BBB in a non-invasive and controlled way may provide the administration of specifically targeted therapeutic agents to a localized area.