Maythem Saeed1, Loi Do1, Steven W. Hetts1, Mark Wilson1
1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, Ca, United States
The purpose of this transitional study was to determine threshold microemboli volume that causes visible microinfarct on MRI and MDCT. Cardiac injury biomarkers and histochemical staining were used to confirm the presence of myocardial injury. Pigs (n=18) received either 16mm3 or 32mm3 volumes of 40-120μm diameter microemboli. Three days after intervention contrast enhanced MDCT and MRI were performed. A threshold method was used to measure microinfarct on MRI/MDCT. Creatine-kinase MB, troponin I and triphenyltetrazolium chloride stain were used to confirmed myocardial injury. MRI and MDCT may be useful in evaluating the effectiveness of new therapies and future distal filtration devices.