Rishi Awasthi1, Sachidanand Srivastava2, Namdeo S. Gajbhiye3, Deepak Tripathi4, Mohit Kumar Rai4, Vikas Agarwal4, Vinita Agrawal5, Rakesh Kumar Gupta1
1Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 2Chemistry, Indian Institute of Technology, Kanpur, Lucknow, Uttar Pradesh, India; 3Chemistry, Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India; 4Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 5Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India
A new type of MR/fluorescence multimodal imaging probe has been developed using fluorescent carbon nanomaterials and Fe3O4 (6 nm) magnetic nanoparticles. The prepared nanocomposite satisfies the primary conditions for both MR as well as fluorescence imaging: i.e (i) superparamagnetic nature; & (ii) wavelength tunable fluorescence properties with high fluorescence quantum yield (QY). The obtained results of in-vivo MR and fluorescence imaging strongly suggest that these multimodal imaging probes can be used as MR contrast agent and equally effective fluorescent biomarker. This novel and facile approach opens up a new route to design carbonaceous based multifunctional nanocomposites for various biomedical applications including various types of multimodal imaging as well as effective drug delivery systems and targeting agents.