Yun-Ming Wang1, Shou-Cheng Wu2, Gyan Singh
1Department of Biological Science and Technology, National Chiao Tung University, HsinChu, Taiwan; 2Department of Biological Science and Technology, National Chiao Tung University, Taiwan
A highly sensitive and specific dual modality T2 weighted MR-optical imaging agents (SPIO-mAb-Cy777 NPs) has been synthesized. The SPIO NPs and Cy777 serves as MR enhancer and NIR optical imaging dye respectively. The anti-MUC4 mAb has been used as targeting moiety to target MUC4 receptor which is exclusively expressed in pancreatic cancer. An ex-vitro and In Vitro experiments shows significant negative contrast enhancement in MUC4 positive cell line, on the contrary contrast enhancement was not observed in MUC4 negatively expressed cell. Therefore, we can conclude that the SPIO-mAb-Cy777 NPs can specifically target MUC 4 receptor and can be potentially used as tool for the detection of pancreatic cancer with high specificity and sensitivity.