Dirk Graafen1, 2, Michael Ryan Hansen2, Laura Maria Schreiber1, Kerstin Mnnemann2
1Section of Medical Physics, Johannes Gutenberg University Medical Center, Mainz, Germany; 2Max Planck Institute for Polymer Research, Mainz, Germany
The aim of the study was to optimize the timing of a PH-INEPT+ sequence for 13C1-Hydroxyethylproprionate (HEP) to enable optimal polarization transfer from hyperpolarized protons using parahydrogen induced polarization (PHIP) to Carbon-13. Spin dynamics simulations showed the different sequence timing behavior of a thermally polarized and a PHIP polarized molecule. In comparison, for this molecule the optimal τ 1 delay of the PH-INEPT+ sequence is ~4ms for the thermal polarization whereas it is ~27.5ms for the hyperpolarized state. Experiments in a 7T spectrometer reproduce the simulation results adequately.