Cline Giraudeau1, Odile Diou2, Nicolas Tsapis2, Philippe Robert3, Caroline Robic3, Marc Port3, Denis Le Bihan1, Sbastien Mriaux1, Fawzi Boumezbeur1, Franck Lethimonnier1, Julien Valette1, 4
1NeuroSpin, I2BM, Commissariat l'Energie Atomique, Gif-sur-Yvette, France; 2Univ Paris Sud, UMR CNRS 8612, Chtenay Malabry, France; 3Guerbet, Research Division, Roissy-Charles de Gaulle, France; 4MIRCen, I2BM, Commissariat l'Energie Atomique, France
In the present work, an original spectroscopy sequence dedicated to PFOB and composed of a diffusion-weighted LASER module followed by an echo train is used to specifically detect angiogenesis in a carcinoma mouse model. We show that this sequence is more sensitive than a conventional LASER sequence and allows detection of sub-nanomolar concentrations of v3-targeted PFOB nanoparticles. By selectively suppress signal coming from nanoparticles in the bloodstream, diffusion allows specific detection of angiogenesis on an individual animal. This method could be a novel concept to detect disease biomarkers by indicating the specificity of the signal provided by imaging.