Francesca Branzoli1, Aranee Techawiboonwong2, Andrew Webb1, Itamar Ronen1
1C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands; 2Department of Electrical Engineering, Mahidol University, Bangkok, Thailand
The phenomenon of diffusion of molecules in biological tissues directly relates to the characteristic length scales of tissue compartments and it has been recognized as a powerful contrast mechanism for deriving information on white matter microstructure. In this study, for the first time the interaction between proton transverse relaxation times (T2) and apparent diffusion coefficients (ADC) was investigated, by means of diffusion-weighted spectroscopy, for both water and metabolites in the human brain at 7T.