Jiri Keller1, 2, Aaron Michael Rulseh1, Arnost Komrek3, Iva Latnerov1, Robert Rusina4, Jiri Klempr5, Katerina Zrubov6, Josef Vymazal1
1RDG, Na Homolce Hospital, Prague 5, Prague, Czech Republic; 2Neurology, 3rd Medical Faculty, Charles University, Prague, Prague 10, Czech Republic; 3Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic; 4Department of Neurology, Faculty Thomayer Hospital, Czech Republic; 5Department of Neurology and Center of Clinical Neuroscience, 1st Faculty of Medicine, Charles University; 6Department of Neurology, 2nd Faculty of Medicine, Charles University, Czech Republic
To facilitate the assessment of fractional anisotropy (FA) in daily clinical practice, we propose a new non-linear colour look-up table (LUT) based on healthy subject data (in the present study 76 volunteers). Our approach can be used to build a site-specific LUT, especially relevant considering the variability of signal-to-noise ratio. The LUT has been tested on a cohort 17 multiple system atrophy (MSA) subjects, 13 Parkinson disease subjects and 17 healthy volunteers. Three blinded radiologists achieved an average sensitivity of 88% (65-100%) and specificity of 93% (80-100%) in differentiating MSA from other groups solely using this method.