Xia Zhao1, Yiqun Xue1, Ramesh Paudyal1, Jiangsheng Yu1, Hyun Seon Kang1, Sarah Englander1, Thomas Ferrara1, Harish Poptani1, Amit Maity2, Ramesh Rengan2, Rosen Mark1, Ping Wang1, Hee Kwon Song1
1Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States; 2Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States
In this work, the standard concentration-based method of computing tissue perfusion was compared with a simpler signal difference method in patients with lung tumors using a 3D radial DCE-MRI sequence. Repeatability of Ktrans is slightly higher in the standard method, and is similar to those observed in previous studies using Cartesian based sequences. The results indicate that even in the absence of intrinsic T1 or accurate flip angle information perfusion parameters can be determined using the signal difference methodology with only minor loss of measurement precision.