Frank Riemer1, Bhavana Solanky1, Matthew Clemence2, Xavier Golay3, Claudia AM Wheeler-Kingshott1
1NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, London, United Kingdom; 2Philips Clinical Science Group, Philips Healthcare, Guildford, United Kingdom; 3Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom
High field MRI,new pulse sequences and improvements in non-cartesian sampled k-space reconstruction has drawn attention to Sodium MRI, a technique directly susceptible to most pathological changes in the brain due to the tight regulation of intra- and extracellular 23Na gradient of which a change alters the sodium signal. It could give new insight into diseases such as Multiple Sclerosis, were disease progression has been postulated to be associated with rise and reduction if intracellular sodium content. In this work, we compare 3 common pulse sequences for SNR and resolution in the brain; as previous studies have focused on phantoms with different properties such as absence of short T2 blurring.