Hai Zheng1, Tiejun Zhao2, Yongxian Qian3, Tamer Ibrahim1, 3, Fernando Boada, 13
1Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; 2Siemens Medical Solutions USA, Pittsburgh, PA, United States; 3Radiology, University of Pittsburgh, Pittsburgh, PA, United States
Susceptibility-induced artifacts lead to geometric distortions and/or signal loss near some important functional regions. This signal loss increases at ultra-high-field and is often located at the sites being investigated with fMRI and must, therefore, be compensated in order to obtain robust activation. In this study, previously reported PTX 3DTRF pulse design is extended to restore the lost signal over the whole brain and increase the BOLD contrast to brain activation in ultra high field. In addition, the compromise between the performance of signal recovery and computational time is also investigated through the effect of trajectory design.