Laleh Golestanirad1, 2, Graham Wright1, Simon Graham1
1Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Laboratory of Electromagnetics and Acoustics (LEMA), Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Metabolic changes in primary tumors can lead to the development of the metastatic phenotype. The objective of this study is to demonstrate the link between LDH-A expression and lactate level in tumors. The LDH-A silenced 4T1 tumors have slower growth rate compare to the control 4T1 tumors. Both nonlocalized- and localized-spectra are acquired using the selective multiple-quantum coherence transfer (SelMQC) sequence in vivo. The LDH-A silenced 4T1 tumors showed a lower level of lactate compare to 4T1 control tumors.