Daniel Jason Aaron Margolis1, Karim Chamie2, Shyam Natarajan3, Nelly Tan1, Jiaoti Huang4, Robert Reiter2
1Department of Radiology, UCLA David Geffen School of Medicine, Los Angeles, CA, United States; 2Department of Urology, UCLA David Geffen School of Medicine; 3Department of Bioengineering, UCLA David Geffen School of Medicine, Los Angeles, CA, United States; 4Department of Pathology, UCLA David Geffen School of Medicine
Determination of eligibility for active surveillance (AS) is based on serum and biopsy findings. We reviewed prostatectomy specimens of 104 men who had presurgical endorectal coil MRI to determine who would have been appropriate for AS based on clinical parameters alone and after adding imaging information, using surgical pathology as the standard of reference. The sensitivity and negative predictive value increased markedly by the addition of the apparent diffusion coefficient of the index tumor using a cut-off of 850 square microns/sec to the clinical parameters alone. This improves diagnostic confidence for men seeking AS.