Basetti Madhu1, Santiago Uribe Lewis2, Adele Murrell2, John R. Griffiths1
1Molecular Imaging, Cancer Research UK Cambridge Research Institute, Cambridge, England, United Kingdom; 2Epigenetics and Imprinting Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, England, United Kingdom
The Apc Min/+ mouse is a genetically engineered cancer mouse model that spontaneously develops tumours in the GI tract. Here we have investigated the metabolic characteristics of the GI tumours of Apc Min/+ mice using HRMAS 1H NMR spectroscopy. We found that amino acid metabolism was significantly affected in tumours relative to the normal adjacent tissues. The total choline content was also increased (though not statistically significantly) whereas total creatine remained unchanged. The data show that HRMAS 1H NMR spectroscopy of Apc Min/+ mouse tumour tissues recapitulates some aspects of the metabolic states observed in human tumours.