Multi Nutrient Enriched Diets Restore Cerebral Perfusion and Protect Against Neurodegeneration in a Mouse Model for Alzheimers Disease

Valerio Zerbi¹, ², Diane Jansen¹, Maximilian Wiesmann¹, Maartje Mutsaers¹, Pieter J. Dederen¹, Ilse Arnoldussen¹, Andor Veltien², Sjaak Van Asten², Arend Hee

Increasing evidence supports the importance of lifestyle especially dietary intake, in sharing a protective action in Alzheimers disease (AD) and cardiovascular diseases. In this study, we therefore evaluated the effects of a long term dietary intake of multi-nutrient lipid diets on cerebral blood flow (CBF) and hippocampal metabolite levels in an AD mouse model (APP/PS1). Results showed that 12-month-old APP/PS1 mice have decreased CBF and that specific combinations of multicomponent enriched diets are able to restore cerebral perfusion into physiological values, with signs of decreased neurodegeneration, suggesting a potential efficacy of multi-nutrient lipid diets in slowing AD progression.