An Vo1, Patricia Gruner1, 2, Toshikazu Ikuta1, 2, Bart Peters1, 2, Anil K. Malhotra1, 2, Peter B. Kingsley3, Aziz M. Ulug1, Philip Szeszko
1Feinstein Institute for Medical Research, Manhasset, NY, United States; 2Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, United States; 3Radiology, North Shore University Hospital, Manhasset, NY, United States
Obsessive-compulsive disorder (OCD) is a disorder of the brain and behavior that is characterized by recurrent worries and repetitive behaviors. Pediatric OCD is similar to OCD in adults. However the content of obsessions and compulsions can be influenced by developmental factors such as age, gender, genetics. Neuro-imaging studies have contributed to our understanding of the neurobiological basis of pediatric OCD. The purpose of this study was to use diffusion tensor image (DTI) derived metrics to explore disease affected circuits in pediatric OCD patients compared to healthy volunteers.