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Abstract #3180

Characterization of Hypoxic Areas in the Human Brain

Nuria Maria Hirsch1, Christine Preibisch1, 2, Vivien Tth1, Jrgen den Hollander1, Annette Frschler1, Hendrik Kooijman3, Claus Zimmer1

1Department of Neuroradiology, Klinikum rechts der Isar der TU Mnchen, Mnchen, Germany; 2Department of Neurology, Klinikum rechts der Isar der TU Mnchen, Mnchen, Germany; 3Clinical Application, Philips Healthcare, Hamburg, Germany


Hypoxia is assumed to promote the development and proliferation of tumor stem cells especially in highly malignant and aggressive tumors The BOLD effect provides a method for oxygenation dependent contrast, but for an absolute quantification of oxygen saturation T2, T2* and CBV have to be measured additionally. In this study, hypoxia was mapped semi-quantitatively from those parameters with an emphasis on fast imaging methods that can easily be employed in the clinic.