Akihiro Asano1, Toshiaki Miyati1, Naoki Ohno2, Kan Hirohito3, Mitsuhito Mase4, Tomoshi Osawa5, Harumasa Kasai3, Nobuyuki Arai3, Masaki Hara3, Yuuta Shibamot
1Department of Health Science, Graduate School of Medical Science, kanazawa university, Kanazawa, Japan; 2Department of Radiological Technology, kanazawa university Hospital, Kanazawa, Japan; 3Department of Radiology, Nagoya City University Hospital, Nagoya, Japan; 4Department of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciencces, Nagoya City University, Nagoya; 5Department of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciencces, Nagoya City University, Nagoya, Japan
We have reported that the apparent diffusion coefficient (ADC) obtained from diffusion MRI in the cerebral white matter significantly changed during the cardiac cycle, and this change (delta-ADC) assisted in the diagnosis of idiopathic normal pressure hydrocephalus (INPH). While a cerebrospinal fluid tap test is one of the useful methods for the diagnosis of INPH. The aim of this study was to assess how much change in the delta-ADC of the brain in INPH before and after the tap test. Delta-ADC analysis makes it possible to noninvasively provide information of change in the intracranial condition after the tap test.