Differential Effects of Fractionated and Single Radiation Dose on Diffusion Tensor Imaging in Mice Brain

Mamta Gupta¹, Richa Trivedi¹, Poonam Rana¹, Ahmad Raza Khan¹, Rajendra P. Tripathi¹, Subash Khushu¹

Longitudinal diffusion tensor imaging (DTI) study was performed at baseline, day 1, day 3, and day 5 after fractionated and single 8gy cranial irradiation of mice brain. A subsequent decrease in FA values were observed at both day3 and day5 in hippocampus in fractionated 8 gy irradiation group, whereas in single 8y irradiation in addition to hippocampus change in DTI measures were also observed in caudate-putamen and corpus callosum regions. Our results demonstrate radiation induced microstructural changes in brain parenchyma even in case of fractionated dose during acute phase even before conventional MRI.