Roberta Messina1, Maria A. Rocca1, Paola Valsasina1, Bruno Colombo2, Andrea Falini3, Giancarlo Comi2, Massimo Filippi1
1Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy; 2Department of Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy; 3Department of Neuroradiology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy
Aim of this study was to quantify abnormalities of cortical thickness (CT) and cortical surface area (CSA) in patients suffering from migraine with different clinical and radiological characteristics. Between-group comparisons and correlations of CT/CSA with clinical and radiological characteristics were performed using a vertex-by-vertex analysis with FreeSurfer. Migraineurs experienced distributed CT and CSA abnormalities, which differed according to patients characteristics. CSA was significantly correlated with clinical variables. In conclusion, abnormalities of CT and CSA occur in patients with migraine.